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Moreover, the observation that adding GLP-1MK-801 treatment on top of semaglutide leads to an additional weight loss of 7% in mice that have reached a weight loss plateau with semaglutide provides additional support for integrating NMDA receptor antagonism in next-generation weight loss therapeutics

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These changes in sugar levels contribute to transient retinal changes in patients who have pre-existing DR, and lead to further questions on what other complications can come about with prolonged usage